As a key transit point on the route, Libya is expected to be a focus of the discussions convened by French President Emmanuel Macron in Paris. The leader of Libya's internationally-backed government, Fayez Serraj, is representing the troubled north African country.
The leaders also plan to discuss security cooperation, and the European leaders will then hold separate talks focused on European Union matters.
A top diplomatic official at the French presidency said the goal of the meeting is to produce a common "roadmap" that would define priority actions on migration routes.
An idea under discussion is establishing "protection missions" in Chad and Niger that would be operated by the United Nations' refugee and migration agencies in cooperation with EU countries' domestic migration agencies. The pre-asylum centers would receive European financing.
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The official, in keeping with French presidential policy, requested anonymity and would not provide details on the precise locations and procedures for the missions.
German Chancellor Angela Merkel said ahead of the meeting that she wants more support for Libya's coast guard and a "migration partnership" with Niger to inhibit migrant smuggling.
While European and African leaders were to meet in Paris, interior ministers from Libya, Chad, Niger and Mali met Monday at Rome's interior ministry Monday morning.
A joint statement after the meeting said the ministers expressed satisfaction with the Paris summit's agenda, which they said "can constitute the beginning of a new relationship between Europe and Africa."
They agreed with the aim of setting up in Niger and Chad and of improving in Libya "reception centers for irregular migrants, coherent with their own legislation, with the aim of bringing them up to international humanitarian standards.
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