The 37-year-old, whose divorce from basketball player Tony Parker was finalized last year, parted ways because of their different schedules and lifestyles, reported Showbizspy.
"Mark adores and respects Eva. It really was about scheduling more than anything else. They will remain close friends. There was no drama. They just have completely different schedules and lifestyles," said Sanchez's representative.
Longoria, who split from Eduardo Cruz in June, confirmed her relationship with the New York Jets quarterback in September, but the brunette is said to be "more focused on her career" than going out on the town.
"He likes to go out and have fun. She's more focused on her career and her philanthropic work," a source said.