He died early today after suffering colon cancer, said his son, Tudor Vasile.
Vasile became prime minister in April 1998. Among other achievements he mediated a violent miners' protest at the Cozia Monastery halfway through a march to the capital which they had threatened to rampage.
Vasile invited and then hosted Pope John Paul II in Bucharest in 1999. The visit was the first visit by a pope to a Christian Orthodox country since the great schism in 1054.
Stresses of the job took their toll on Vasile, who suffered a heart attack in 1999 and vowed to quit smoking two packets a day.
He was fired by President Emil Constantinescu in December 1999 amid workers' protests and infighting in the government. President Traian Basescu praised Vasile for leading Romania a turbulent time, joining in tributes by former presidents Ion Iliescu and Constantinescu.
Vasile will be buried Friday at the Bellu Catholic cemetery.