Lopez has in recent months moved global commodity markets with a campaign to close roughly two-thirds of the existing mines in the Philippines, which is the world's biggest supplier of nickel ore and a major source of copper.
For the 63-year-old, her sudden elevation by firebrand President Rodrigo Duterte to government last year after a lifetime of spiritual and environmental pursuits has presented an unexpected chance to bring about radical change in society.
"Not everyone has the guts and the wherewithal to stand on big business's toes. Right now I have that platform."
Lopez casts mining in a sinister light, accusing powerful business figures and politicians involved in the industry of corruption and rapaciousness.
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She insists mining is destroying the Southeast Asian archipelago's ecosystem, and that the natural resources on offer can be used in much more sustainable ways.
Lopez has ordered the closure or suspension of 28 mines which, if implemented, would leave just 12 in operation. She has also recommended the contracts of 75 planned mines be cancelled to protect watersheds.
Mining Inc is fighting back, with a public relations blitz insisting it is a law-abiding industry that generates billions of dollars for the economy and directly supports 1.2 million people.
It has appealed to Duterte, who has spoken fiercely against the industry but nevertheless also has many pro-mining figures in his cabinet, to over-rule Lopez.
"This is the first time we have opposed an appointee of the president," Chamber of Mines of the Philippines vice president Ronald Recidoro told AFP.
"We've had to because our existence is on the line. If she is confirmed the mining industry is finished, we are done."
If Lopez survives as environment secretary and gets to serve her full six-year term, she has much bigger plans for remodelling the Philippine economy -- and she is taking inspiration from the tiny Himalayan nation of Bhutan.
"I love the Bhutan model," Lopez said.
"They know if they kill their air, they kill their water, they will never ever be happy. And I find that quite enlightened."
Lopez has walked an unlikely path to becoming one of the most powerful women in the Philippines. She belongs to one of the wealthiest families in the country.
But Lopez exchanged a life of luxury as a young lady for one as a yoga missionary with a spiritual organisation founded in India called Ananda Marga, or Path of Bliss.
Back home Lopez earned a reputation as a passionate advocate for the environment, most notably with the charitable arm of her family's ABS-CBN media empire.