Four-fifths of these additional premature deaths due to nitrogen oxide (NOx) pollution occurred in three regions - the European Union, China and India, researchers reported in the journal Nature.
NOx are poisonous gases that contribute to acid rain and combine with ammonia to create particles that can penetrate deep into the lungs and cause cancer, chronic breathing problems and premature death.
Until recently, estimates of deaths attributable to NOx pollution was based on levels reported by vehicle makers.
The new study of 11 major car markets -- the others are Australia, Brazil, Canada, Japan, Mexico, Russia, South Korea and the United States - revealed that diesel vehicles spewed at least 50 per cent more NOx under real-world driving conditions than their makers claimed.
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That translates to 38,000 deaths due to "excess" emissions, out of an estimated total of 107,000 lives foreshortened to diesel car and truck fumes in 2015, the researchers found.
Long-term exposure is linked to disability and premature death due to stroke, heart disease, lung cancer, and chronic obstructive pulmonary disease (COPD) - a degenerative condition of the lungs.
The elderly are especially vulnerable.
"The consequences of excess diesel NOx emissions for public health are striking," said lead author Susan Anenberg, co-founder of Environment Health Analytics, a policy research group based in Washington DC.
Commercial trucks and buses are by far the biggest culprit worldwide, accounting for more than three-quarters of excess NOx output.
For light-duty vehicles - small trucks, cars and vans - the EU produced nearly 70 per cent of global excess NOx emissions, the study found.
A earlier study calculated that pollution from 2.6 million Volkswagen cars equipped with test-evading software and sold in Germany from 2008 to 2015 will cause more than 1,200 premature deaths in Europe.
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