Assad also said he had no knowledge of the deadly chemical attack allegedly carried out by his own military and criticised US Secretary of State John Kerry for making the charges without "a single shred" of evidence.
In a clear reference to his allies in Iran and the Islamic militant group Hezbollah, Assad warned that his government is "not the only player in this region."
"You have different parties, you have different factions, you have different ideology. You have everything in this region now," said Assad, who has been accused by the White House of killing 1,400 of his own people in an August 21 chemical weapons attack on the Damascus suburbs.
Assad's warning comes comes at the start of a pivotal week for US President Barack Obama. The Senate is expected to take up the resolution after returning from its month-long summer recess today and Obama does a round of interviews with the major American broadcast and cable news outlets.
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The Syrian president denied using chemical weapons against his own people as alleged by the US and other Western powers.
"We-- we're not in the area where... The alleged chemical attack was happened, as is alleged. We're not sure that anything happened," Assad insisted.
"Our soldiers in another area were attacked chemically, our soldiers. They went to the hospital, as casualties because of chemical weapons. But in the area where they said the government used chemical weapons, we only had video and we only have pictures and allegations. We're not there. Our forces -- our police, our institutions don't exist. How can you talk about what happened if you don't have evidences?
"He presented his confidence and he presented his convictions," Assad said of Kerry. "It's not about confidence, it's about evidence..."
In this case, Kerry didn't even present any evidence. He talks, 'we have evidence,' and he didn't present anything, not yet. Nothing so far... Not a single shred of evidence.