Architects and scientists from Egypt, France, Canada and Japan will use modern infra-red technology and advanced detectors to map two pyramids at Giza and the two Dahshur pyramids, south of Cairo.
"This special group will study these pyramids to see whether there are still any hidden chambers or other secrets" inside them, Minister of Antiquities Mamduh al-Damati announced at a news conference.
"These engineers and architects will conduct the survey using non-destructive technology that will not harm the pyramids," he said.
Many previous missions have attempted to unravel the mysteries of the pyramids, but archaeologists and scientists have yet to come up with a concrete theory explaining how the structures were built.
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Khufu's pyramid, also known as the Great pyramid of Giza -- the tallest of all the pyramids -- was built by the son of Snefru, founder of the fourth dynasty (2,575-2,465 BC), while the Khafre's pyramid or Chephren was built by the son of Khufu.
"The idea is to find the solution to the mystery of the pyramids," said Mehdi Tayoubi, founder of Paris-based HIP Institute that is participating in the project.
"A similar attempt was made 30 years ago, but this is the first project at a global level using cutting-edge technology to look inside the pyramids," he told AFP.
Project "Scan Pyramids" is expected to last until the end of 2016.
Damati said the "infra-red and muon" technologies that would be used to search the four pyramids could also be useful to look for a possible hidden chamber in King Tutankhamun's tomb, which may be the burial place of Queen Nefertiti.
Reeves, who was in Luxor in September to probe his theory, believes one door of Tutankhamun's tomb could conceal the burial place of Nefertiti.
Egypt has already approved using radars to search the boy king's tomb, which was found by British Egyptologist Howard Carter in 1922.