While most of the fans were saddened with news, many romanticised about the possibility of Aniston and her former husband Brad Pitt getting back together.
Aniston,49, and Theroux,46, today announced that they are separating after more than two years of marriage.
The duo dated for four years after meeting on the sets of the film "Wanderlust" in 2011. They tied the knot in 2015.
Their separation opened floodgates on Twitter, with many reacting with hilarious memes and GIFs.
More From This Section
"Im so saddened by this news of Jennifer Aniston separating from her husband. Honestly, I never liked Justin Theroux. He seems slimy. She can do so much better. I wish her all the best," fan Abusa Dora tweeted.
"Not to sound trivial with all of the terrible news breaking these last few days but I'm sad to hear that Jennifer Aniston and Justin Theroux are separating!" said another user.
"What if Jennifer Aniston and Brad Pitt start dating," another user wrote.
"People are actually happy Jennifer Aniston is divorcing Justin Theroux isn't that creepy. Most divorce, even if necessary is painful and decent people wouldn't wish it on anyone. And if they want a Brad/Jen reunion, its sad. Real people, not our fantasies," a user tweeted.