The incident took place in the wee hours of Friday when thieves broke the lock to enter the store located on the main thoroughfare in the South Extension Part II market.
Police registered an FIR at Hauz Khas police station and further investigation is on.
"An estimated loss of Rs 50 lakh to Rs 60 lakh altogether has happened in the theft of the clothes and cash," said a police officer quoting the FIR in the case.
Her entire bridal couture collection along with cash generated from the daily sales and all the IT hardware have been stolen, an official statement said.
The district police commissioner is personally looking into the matter and there are hopes of breakthrough in the incident soon, an official statement said.