Andrew Butler, professor of pharmacological and physiological science at Saint Louis University, and his lab discovered the peptide hormone adropin several years ago.
Adropin regulates whether the body burns fat or sugar during feeding and fasting cycles.
"Adropin is a poorly understood hormone," Butler said.
"We first reported its discovery a little over six years ago, but we really didn't understand what it did. We knew it played a role in maintaining metabolic health, but we didn't know much beyond that," he added.
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"When we measured adropin levels in mice, they were suppressed under fasting conditions and stimulated after feeding, suggesting functions related to the changes in metabolism that occur with feeding and fasting," Butler said.
"Our work suggests that adropin plays a role in regulating metabolic (energy) homeostasis," Butler added.
"Basically, when you are well fed, your body prefers to use glucose and the release of adropin supports this change by enhancing the use of glucose as a metabolic fuel in muscle.
Building on that work, researchers in a new paper in the journal Molecular Metabolism reported that low levels of the hormone observed in obesity may contribute to diabetes and the reduced ability of the body to use glucose.
The team found that treatment with adropin improved glucose tolerance, enhanced insulin action and improved metabolic flexibility toward glucose utilisation in situations of obesity and insulin resistance.