A bench of Chief Justice G Rohini and Justice Sangita Dhingra Sehgal asked the probe agency to furnish the "latest status report" in the matter by December 9, the next date of hearing.
"You (CBI) file the latest status report as several cases are there," the bench told the CBI counsel.
Former Chief Vigilance Officer (CVO) of AIIMS, Sanjeev Chaturvedi, had earlier accused the Health Ministry of not doing anything in several graft cases relating to the institution by allegedly sitting over the charge sheets and CBI reports against the individuals involved.
The PIL by NGO Centre for Public Interest Litigation has also sought a CBI probe into various graft cases in AIIMS.
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Health Minister J P Nadda had earlier told the court that the PIL was "actuated by ulterior motive" to gain political mileage and "malign" the government's image.
In his reply, he had refuted allegations that Chaturvedi was removed from the post as he was conducting a probe in several graft cases related to malpractices in the AIIMS.
Earlier, Chaturvedi had claimed in his first affidavit that previous Health Minister Harsh Vardhan as well as CBI had recommended major penalty proceedings against some AIIMS officials in connection with alleged irregularities in the construction of porta cabins at the Jhajjar campus of the institute but no action had been taken.
The Ministry of Health and Family Welfare, in its reply, had also termed as "incorrect" that after Chaturvedi's removal as CVO, no vigilance office is functioning at AIIMS as a Joint Secretary-rank official has been assigned charge of the post.