Saudi civil defence said 60 people had evacuated their homes when the fire broke late yesterday in Al-Balad, a historic district in the Red Sea city of Jeddah which dates back to the 8th century.
The blaze completely destroyed three buildings and seriously damaged three others, civil defence said. There were no reports of injuries.
Jeddah, Saudi Arabia's second largest city after the capital Riyadh, is listed as a UNESCO world heritage site.
The city is home to 19th century houses known for their Roshan, a distinctive wooden facade.