The emergency services rushed to the couple's LA mansion on Monday and were later spotted chatting to a passer-by walking his dog before vacating the residence, reported InTouch magazine.
It is not yet known why the firemen and medical team were called to the property and whether Jolie, 39, Pitt, 51, and their six children, Maddox, 13, Pax, 11, Zahara, 10, Shiloh, eight, and six-year-old twins Vivienne and Knox were at home during the incident.
However, it is likely the couple were in the area at the time after stepping out together at the American Society of Cinematographers 29th Annual Outstanding Achievement Awards held at the nearby Hyatt Regency Century Plaza near Beverly Hills on Sunday.
They were also seen responding to a call at their neighbour Giovanni Ribisi's five-bed home, which he shared with his then-wife, model Agyness Deyn, in October 2012.