Reno died at her Miami home due to complications from Parkinson's disease, her sister Maggy Hurchalla told CNN.
The top US law enforcement officer throughout Clinton's 1993-2001 presidency, Reno came under fire barely one month after becoming attorney general for her handling of a botched April 1993 FBI raid on an armed religious cult in Waco, Texas.
Some 80 people died when the Branch Davidian cult's compound went up in flames.
One of the longest-serving US attorney generals, her Department of Justice handled prosecutions in the 1993 World Trade Center bombing and two cases of domestic terrorism, the 1995 Oklahoma City federal building bombing and the "Unabomber" Ted Kaczynski.
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Reno was born in Miami on July 21, 1938, the daughter of Henry and Jane Reno, two newspaper reporters.
She was one of only 16 women in the 500-strong 1960 class at Harvard Law School, where she received her degree three years later.
Reno chaired the Florida Governor's Council for the Prosecution of Organized Crime in 1979-80.
Upon leaving office Reno, who was six foot, two inches tall, saw her bid to run for governor in 2002 thwarted when she narrowly lost in the Democratic party primary.
Her post-government work included a 2013 appearance as a guest character on the animated show "The Simpsons.
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