The announcement answered one of the lingering questions surrounding the first family's unusual living arrangement. Mrs Trump and 11-year-old Barron have been living at Trump Tower in New York since Donald Trump took office in January, while the president has lived at the White House.
Trump has said his wife and youngest child will relocate to the White House after the current school year ends, which meant finding a local school for Barron.
Mrs Trump said today that they have chosen St Andrew's Episcopal School in Potomac, Maryland, for their son.
Annual tuition ranges from more than USD 23,000 for pre-K to more than USD 40,000 for students in grades 9-12.
"We look forward to the coming school years at St. Andrew's," Mrs. Trump said.
Founded in 1978, St Andrew's, a day school, has a total enrollment of 580 students in prekindergarten through 12th grade, according to its website. Class sizes are small, with anywhere from 11 to 13 students, and all of its graduates go on to college, the school said.