The poster sees Nawazuddin, who plays a notorious serial killer, with red eyes and lug wrenches sticking out of his head, giving him an evil Medusa-like look.
"And here comes the first look of RAMAN RAGHAV 2.0 @Nawazuddin_S," Kashyap wrote on Twitter alongside the picture.
The movie also stars "Masaan" actor Vicky Kaushal, who plays a cop.
"Raman Raghav 2.0" will premiere at the Cannes Film Festival's 'Directors Fortnight' section this year.
It will release in India on June 24.