Fish oil may stall effects of junk food on brain

Fish oil could minimise the damaging effects that junk food can have on the brain, according to new research.
Scientists at the University of Liverpool analysed research papers from around the world to see whether there was sufficient data available to suggest that omega-3s had a role to play in aiding weight loss.
Previous research has indicated that high-fat diets could disrupt neurogenesis, a process that generates new nerve cells, but diets rich in omega-3s could prevent these negative effects by stimulating the areas of the brain that control feeding, learning and memory.
Data from 185 research papers revealed, however, that fish oils do not have a direct impact on this process in these areas of the brain, but are likely to play a significant role in stalling refined sugars and saturated fats' ability to inhibit the brain's control on the body's intake of food.

"Body weight is influenced by many factors, and some of the most important of these are the nutrients we consume," said Dr Lucy Pickavance, from the University's Institute of Ageing and Chronic Disease.
"Excessive intake of certain macronutrients, the refined sugars and saturated fats found in junk food, can lead to weight gain, disrupt metabolism and even affect mental processing.

"These changes can be seen in the brain's structure, including its ability to generate new nerve cells, potentially linking obesity to neurodegenerative diseases.
"Research, however, has suggested that omega-3 fish oils can reverse or even prevent these effects.
"We wanted to investigate the literature on this topic to determine whether there is evidence to suggest that omega-3s might aid weight loss by stimulating particular brain processes," Pickavance said.

Research papers showed that on high-fat diets hormones that are secreted from body tissues into the circulation after eating, and which normally protect neurons and stimulate their growth, are prevented from passing into the brain by increased circulation of inflammatory molecules and a type of fat called triglycerides.
Molecules that stimulate nerve growth are also reduced, but it appears, in studies with animal models, that omega-3s restore normal function by interfering with the production of these inflammatory molecules, suppressing triglycerides, and returning these nerve growth factors to normal.
"Fish oils don't appear to have a direct impact on weight loss, but they may take the brakes off the detrimental effects of some of the processes triggered in the brain by high-fat diets," Pickavance said.

"They seem to mimic the effects of calorie restrictive diets and including more oily fish or fish oil supplements in our diets could certainly be a positive step forward for those wanting to improve their general health," Pickavance added.
The research was published in the British Journal of Nutrition.