The incident occurred when the vehicle, which was on its way from Baskhari to Akbarpur, developed a technical problem.
Despite his attempts, the driver lost control of the vehicle and it crashed into a roadside tree on Akbarpur- Azamgarh road in the Baskhari police station area, SP Sunil Saxena said.
Efforts to identify the victims were on and the injured were taken to a nearby hospitals, police said.
Ambedkar Nagar is about 200 km from state capital Lucknow.