Police said condition of two of those hospitalised was critical. The deaths occurred last night in Larkana city, the hometown of the Bhutto family and a stronghold of the Pakistan People's Party that rules Sindh.
Several Muslims, a Christian and one Hindu were among the dead.
Toxic home-brewed liquor claims many lives, especially during festival holidays, in Pakistan as the poor cannot afford expensive alcohol sold by bootleggers.
Although alcohol consumption is banned in Pakistan, non- Muslim minorities can obtain liquor from government controlled shops. Most of the alcohol available for minorities is sold in the black market at a premium.
In August last year, 10 people died after drinking poisonous liquor in Mehmoodabad area in Karachi.