Most of the deaths occurred near the island of Kastellorizo, where an American-flagged sailing boat said it had rescued nearly a dozen people, with a dead infant among them.
A subsequent search by coastguard vessel recovered the bodies of a boy and two women and crews are still searching for a missing man, the coastguard said.
In a separate incident, an eight-year-old boy of apparent Iraqi origin was confirmed dead on arrival on the island of Farmakonissi.
Nearly 300 people trying to escape conflict and poverty in their home countries have died in the Aegean Sea this year according to the International Organisation for Migration (IOM).
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With winds in the Aegean now reaching 50 kilometres (30 miles) an hour, deadly sinkings occur nearly every day.
The UN refugee agency UNHCR has reported an increase in the number of migrant boats arriving from Turkey this week.
"The surge in arrivals could be the result of a temporary improvement in the weather, a rush to beat the onset of winter, and a fear that European borders may soon close," UNHCR said Friday.