The vaccine's heart protective effects may be even greater among those who receive a more potent vaccine, found the study led by Dr Jacob Udell, a cardiologist at Women's College Hospital and clinician-scientist at the University of Toronto.
"Our study provides solid evidence that the flu shot helps prevent heart disease in vulnerable patients - with the best protection in the highest risk patients," Udell said.
The researchers found people who received the flu shot had a 36 per cent lower risk of a major cardiac event (heart attack, stroke, heart failure, or death from cardiac-related causes) one year later.
They also had a 55 per cent lower risk of a major cardiac event if they had a recent heart attack and were less likely to die from cardiac-related and other causes.
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Those who received the flu shots were also less likely to have a major cardiac event with a more potent vaccine compared with the standard seasonal vaccine, the study found.
The study was published in the Journal of the American Medical Association.