The regional situation ahead of the drawdown of NATO troops in Afghanistan next year and the latest developments in Bangladesh, Iran and Syria will also prominently figure in Singh's meetings with her American interlocutors.
Her four-day Washington visit is part of efforts by India and the US to implement decisions made by Prime Minister Singh and President Obama during their meeting at the White House.
During their meetings, Singh and US officials are expected to ensure that the important relationship is not distracted or paused at a time when India is preparing for a general election.
The wide range of consultations Singh will hold on political and diplomatic issues, ranging from the Middle East to the Far East, is reflective of the depth of the India-US relationship, officials said.
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During her visit, Singh would hold "foreign office" consultations on Tuesday at the State Department with Under Secretary of State for Political Affairs Windy Sherman.
Singh is also expected to hold meetings at the Pentagon and the Department of Commerce.
"It (talks) will be bilateral, but it would also be issues of regional interest, what's happening in India's neighbourhood, which is not only Afghanistan and Pakistan, but also the Maldives, Nepal and most importantly Bangladesh," a source said.
"The latest developments in Iran would figure prominently in the talks, especially discussion on the challenges that are likely to come up in the next six months," the source said.
On energy, the Foreign Secretary is expected to pursue the shale gas issue to address New Delhi's galloping energy needs, sources said.