Heller's cousin, Gary Ballen, says Heller died yesterday night in Southern California.
Heller started his career in the 1960s as an agent and promoter, working with such acts as Pink Floyd, Marvin Gaye and Creedence Clearwater Revival.
He co-founded Ruthless Records with Eazy-E, which released NWA's seminal album "Straight Outta Compton" in 1988, launching the West Coast gangsta rap movement.
Ruthless was also behind such artists as JJ Fad, Michel'le and Bone Thugs-N-Harmony.
Heller released "Ruthless: A Memoir" in 2006.
Actor Paul Giamatti played Heller in last year's hit film "Straight Outta Compton."
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