"We are heartbroken to share the news that our beloved Jim 'Bear' Brady has passed away after a series of health issues," his family said in a statement, according to NBC News. The White House press briefing room is named after him.
The news broke, during the daily White House news conference by Press Secretary Josh Earnest.
"I was aware that Mr Brady was in failing health in recent days, and I was saddened when I first learned of that," Earnest told reporters.
"He leaves a legacy that certainly this press secretary and all future press secretaries will aspire to live up to," Earnest said.
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"Jim touched the lives of so many and has been a wonderful husband, father, friend and role model," his family said in the statement.
"Jim Brady's zest for life was apparent to all who knew him, and despite his injuries and the pain he endured every day, he used his humour, wit and charm to bring smiles to others and make the world a better place," the statement said. Brady last visited the White House press briefing room in June 2009.
Less than three months after being named press secretary, Brady was shot in head on March 30, 1981, while he walked beside the president outside a Washington hotel.
Later, he recovered enough to be a leading national advocate for gun control.