The clashes took place last night in the West Azerbaijan province in northwestern Iran, IRNA said quoting regional governor Hussein Sivani.
He said the clashes pitted members of the Revolutionary Guards against fighters from the Party of Free Life of Kurdistan (PJAK) "terrorist group".
"Two PJAK terrorists were killed and five were injured," Sivani said, adding that the fighting also claimed the lives of two Revolutionary Guards members while two others were wounded.
The Kurdistan Workers' Party has been staging daily attacks against Turkey's armed forces as the military presses an operation against the outlawed group in the southeast and northern Iraq that began in July.
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PJAK rebels have frequently clashed with Iranian forces, sparking retaliatory bombing in the mountainous border districts of the autonomous Kurdish region in neighbouring Iraq.
IRNA, quoting a security official, also reported on today that an attack last week by PJAK militants in the western province of Kermanshah has also killed a Revolutionary Guards member.