The accident occurred early this morning near Bhanipura police station circle when the bus was on its way to Churu from Punjab, they said.
Two children were among the dead, police said adding that 15 critically injured have been admitted to the SMS hospital in Jaipur.
In another road accident which occurred late last night in Karauli district, two persons were killed and three others injured when a tempo collided with a truck in Kotwali police circle.