The mishap took place near Aland Phata late last night, when two SUV cars collided head-on at the highway, Assistant Police Inspector Narsigh Shinde of Wadodbazar Police Station said.
Due to impact of the crash, four of the passengers in the cars died on the spot, he said.
They were identified as Mangala Zhavar (47), Dashrat Bawaskar(38), Sohail Pathan (27) and Dwarkesh N Zhanvar (18).
Two of the injured -- Somnath Zhavar and Shaikh Arif were admitted to the Government Medical College and Hospital here, while the third one is yet to be identified, Shinde said.