The mishap occurred at around 11.30 PM last night near Chendrappinni area when the victims were going to Cochin International Airport from Wayanad.
The deceased were identified as - Muhammad Shan (22), Vineesh (19), Sujith (28) and Shinet Thomas (19),police said.
The injured have been hospitalised.
The victims, all friends, were travelling to the airport to drop Vineesh, who was to travel to Dubai.