The accident took place in the wee hours around 4 AM on the Expressway passing from Dajpura village in Kheda district when the car driver lost control after one of the tyres burst and was hit by the bus.
The deceased were identified as Lila Bhojak (65), Bhanu Bhojak (45), Sonal Bhojak (40) and Dharmendra Bhojak (40), police said.
The injured comprise the car driver Farookh Saiyad and five members belonging to two families related to each other.
On learning about the accident, Mahemdavad police rushed to the spot. In his police complaint, Saiyad alleged that the unidentfied bus driver fled from the spot after the accident.