The mishap occurred when the driver of the vehicle, which was overloaded, lost control over it while negotiating a sharp turn, said Chintapalle Deputy Superintendent of Police (DSP) R Raghavendra.
DSP said the passengers in jeep were going to Chintapalle for shopping.
The victims were identified as Gunnamma (30), S Bhemalamma (62), G Balaram (40) and J Ramarao (35).
Out of the 18 persons injured in the mishap, ten persons were shifted to Narsipatnam area hospital and rest at Chintapalle Hospital, the DSP said, adding they are out of danger.