The incident occurred near Gadhi Sahiram village when their car rammed into a divider in the wee hours today, SP (Rural) Ajay Kumar said.
Suman (24) and Savitri (55) were killed on the spot while Aman (28) and Vishal died on the way to hospital, he said, adding that locals saved the injured and rushed them to Medical College Agra.
The locals lashed out at Expressway police for reaching late on the spot.
Prima Facie it appears that Aman dozed off while driving the car and it rammed into the divider, he said.
The bodies have been sent for post mortem, he said.
A case has been registered in this regard, the SP said, adding that the condition of other injured is stated to be out of danger.