The boys are believed to be aged between 13 and 14.
Police found the man stabbed at his home in The Broadway in Edmonton yesterday evening.
Detective Neale Baldock who leads the murder investigation said: "Our initial enquiries have established there was a supervised party taking place at another address within the block and the group of males were trying to gain access to this", the BBC reported today.
Police officers suspect there was a "verbal altercation" between the victim and a group of boys trying to gain entry to a party in a block of flats.
"The victim and this group were not known to each other. What started as a minor verbal altercation has escalated into a shocking act of violence," the police said.