Fabius's comments came a day after US Secretary of State John Kerry acknowledged that talks with Assad were necessary to bring the bloody conflict in Syria to an end as it enters its fifth year.
"The solution is a political transition which would preserve regime institutions, not Mr Bashar al-Assad. Any other solution which would keep Mr Assad in the saddle would be an absolutely scandalous, gigantic gift to Daesh," Fabius said in Brussels, using another name for IS.
The French minister said he had spoken to Kerry today and that the top US diplomat "assured me that there was absolutely nothing new in the American position on Syria."
Yesterday Kerry's spokeswoman had quickly clarified the remarks that the US envoy made in a television interview, insisting that Washington's policy was unchanged and Assad had no role in Syria's future.
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Washington has previously insisted the US must step aside and can have no role in Syria's future.
EU foreign policy chief Federica Mogherini said that she understood Kerry was referring to the Syrian regime and not Assad.