The Monday report said Jean-Yves Le Drian will hold meetings with Iran's President Hassan Rouhani and Foreign Minister Mohammad Javad Zarif.
Le Drian's office says a key part of the trip will be diplomacy over the war in Syria and trying to get Iran to use its influence on Syrian President Bashar Assad to agree to a cease-fire.
This is the third time that a high-ranking French official visits Iran after the 2015 nuclear deal with world powers. France increasingly has criticized Iran's ballistic missile program since the deal.