In a surprise decision, Defence Minister Sylvie Goulard announced today she was resigning over a fake jobs scandal that has hit her small centrist MoDem party, which allied with Macron's party in the presidential and legislative elections.
Macron accepted her resignation and said he "respected" Goulard's decision.
Her high-profile departure came after the president yesterday asked a close ally, Richard Ferrand, to leave his post as minister for territorial cohesion for a senior role in their Republic on the Move (REM) party.
Goulard's MoDem party is facing a preliminary probe into claims it misused European Parliament expenses in the hiring of parliamentary assistants.
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The minister, who was a member of the European Parliament from 2009 to May this year, said she could not remain in the government while facing a possible investigation.
Meanwhile Macron has been carrying out a partial reshuffle of his month-old government following parliamentary elections on Sunday that handed him and his MoDem allies a commanding majority.