The announcement came after a day of rumours in the French media that Hollande would formally announce the rupture roday, on the eve of a planned visit by Trierweiler to India for charity work.
Saying he was speaking as a private individual, Hollande told AFP: "I wish to make it known that I have ended my partnership with Valerie Trierweiler."
Trierweiler, 48, remains holed up in a presidential residence in Versailles outside Paris after leaving hospital last Saturday, where she was treated for a bout of "tiredness" brought on by press revelations of Hollande's affair with actress Julie Gayet, 41.
Hollande, 59, announced his separation from Segolene Royal, a senior member of his Socialist party and a presidential candidate in 2007, just after she lost the election to Nicolas Sarkozy.
Trierweiler is not married to Hollande but assumed the role of First Lady at official functions after Hollande's election in 2012.