Francois Hollande's message was welcomed by his Israeli hosts, who have voiced concerns that an emerging deal with global powers gives Iran too much without getting enough in return.
"France will not make concessions on nuclear proliferation," Hollande said at a welcome ceremony at Israel's international airport. "France will maintain all its measures and sanctions until we are certain that Iran has renounced nuclear weapons."
Iran's suspect nuclear program will be high on the agenda of Hollande's visit. France is a member of the six global powers conducting negotiations with Iran.
The six powers negotiating with Iran, the US, Russia, China, France, Britain and Germany, failed to reach an agreement earlier this month. The US has expressed optimism that an initial deal can be wrapped up at the next round of talks, providing a six-month period to reach a final agreement.
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Netanyahu's strong objections have raised tensions with the US, which said his concerns are premature. US officials, seeking to calm concerns in Israel and among its allies in Congress, say Iran will get only minor relief from the painful sanctions under the international proposal.
Hollande, accompanied by his girlfriend Valerie Trierweiler, was welcomed by an honor guard at Ben-Gurion International Airport near Tel Aviv. With trumpets playing in the background, a line of politicians, religious leaders and other dignitaries greeted the French leader.