The study by University of Warwick found that school mobility during childhood heightens the risk of developing psychotic-like symptoms in early adolescence by up to 60 per cent.
Suffering from psychotic-like symptoms at young age is strongly associated with mental health problems in adulthood, including psychotic disorders and suicide.
"Changing schools can be very stressful for students. Our study found that the process of moving schools may itself increase the risk of psychotic symptoms - independent of other factors," said Professor Swaran Singh, who led the study.
At the age of 12, participants in the study were interviewed to assess for the presence of psychotic-like symptoms including hallucinations, delusions and thought interference in the previous six months.
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Those that had moved school three or more times were found to be 60 per cent more likely to display at least one definite psychotic symptom.
The authors suggested that moving schools often may lead to feelings of low self-esteem and a sense of social defeat.
This feeling of being excluded from the majority could also render physiological consequences leading to sensitisation of the mesolimbic dopamine system, heightening the risk of psychotic-like symptoms in vulnerable individuals.
"Schools should develop strategies to help these students to establish themselves in their new environment," said Winsper.
The study was published in American Academy of Child and Adolescent Psychiatry.