The bus was flagged off by Road Transport and Highways Minister Nitin Gadkari here at a time when Prime Minister Narendra Modi is in Kathmandu to attend 18th SAARC (South Asian Association for Regional Cooperation) Summit from November 26-27.
While Modi has promised to foster better ties with neighbours, there are expectations that some concrete agreements could be inked during his current Nepal visit in the areas of connectivity and development cooperation.
Terming the occasion "historic", he said, "Government is working to launch similar services for other SAARC nations. Delhi Lt Governor Najeeb Jung was present on the occasion.
This is the second international bus service being operated by the DTC, which has been running Delhi-Lahore International service since 1999.
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It will travel via Yamuna Express Highway, Agra, Firozabad, Kanpur, Lucknow, Gorakhpur and Sunauli. Thereafter, it will enter Nepal territory to reach Kathmandu.
The service will be a direct one and will neither pick up nor drop any passenger anywhere in between. A provision of advance booking has been kept. The passengers will have to carry proof of identification while purchasing the ticket.