But the four thieves on mopeds bungled up and crashed into a lamp post as they fled, dropping some of their loot worth thousands of pounds.
Scotland Yard flying squad officers, called to the scene, appealed for information and witnesses following the theft.
The men broke the front windows of the Old Bond Street shop and took as many handbags as they could carry before speeding off on two mopeds just before 1.30 am.
But police said officers were notified a short time later that a moped had been in collision with a lamp post in nearby Conduit Street, and a number of handbags were recovered.