The star batsman suffered a twinge in his right hamstring while warming-up shortly before the toss in Thursday's second ODI in Nottingham -- his 38th birthday.
It turned out to be a good match to miss, with only 2.2 overs bowled before rain led to a no-result washout that left England 1-0 up in this five-match series.
But the big-hitting Jamaica left-handed opener is now set to be available as West Indies look to draw level in Bristol this weekend.
"It's good to have him back. We hope we can have him for the duration of the series."
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Gayle has scored over 9,000 runs in 265 ODI innings, including 22 hundreds, at an average of more than 37 and with a strike rate in excess of 85.
He only arrived in England for the white-ball leg of West Indies' tour, having effectively made himself ineligible for the preceding 2-1 Test series loss by not not taking part in domestic first-class cricket in the Caribbean.
The match in Manchester was Gayle's first ODI since the the 2015 World Cup following his protracted contractual dispute with West Indies cricket chiefs.
"He definitely brings a lot to the team, a wealth of experience, and his record speaks for itself," added Holder.
"If it's his day, and he gets hold of it, the way he hits it it's going to clear the ropes.
"So you do want to get him early, and we've looked at footage and we've got a rough idea where we want to bowl to him," the Yorkshire left-arm paceman added.
But while Gayle is set to bolster West Indies; batting, the tourists do have a doubt over the fitness of bowler Kesrick Williams.
"We started to bowl last time, and then he was unable to take the field," said Holder.
"I think he should be all right going into the game, but we're still not entirely sure."
At 1-0 down with three to play, West Indies know another defeat will scupper their hopes of coming out on top in this campaign.
"There's definitely still an opportunity to win this series," Barbados all-rounder Holder said. "We head into these last three games with full confidence."
"It's obviously a very sad time," he said.
"Dominica has suffered such damage. Just recovering from the previous hurricane (Irma), to be hit by another one of this magnitude is devastating.
"Our thoughts and prayers are with the people there.
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