"The social, health and security-related ramifications of the high population density and overcrowding are among the factors that may render Gaza unliveable by 2020," the UN Conference on Trade and Development (UNCTAD) wrote in its annual report.
Gaza, a tiny enclave of just 362 square kilometres (about 225 square miles) squeezed between Israel, Egypt and the Mediterranean Sea that is home to some 1.8 million Palestinians, counts one of the highest population densities in the world.
While the high density is not new, the situation has been exacerbated by three Israeli military operations in the past six years and nearly a decade-long economic blockade.
The blockade had "ravaged the already debilitated infrastructure of Gaza, shattered its productive base, left no time for meaningful reconstruction or economic recovery and impoverished the Palestinian population in Gaza," the report said.
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"Short of ending the blockade, donor aid... Will not reverse the ongoing de-development and impoverishment in Gaza," it said.
Socio-economic conditions in Gaza today are currently "at their lowest point since 1967," when Israel seized the territory from Egypt in its Six-Day War, according to the report.
The 2014 war, which also left 73 Israelis dead, destroyed or severely damaged more than 20,000 Palestinian homes, 148 schools, 15 hospitals and 45 primary healthcare centres, UNCTAD said.
As many as 247 factories and 300 commercial centres were fully or partially destroyed, and Gaza's only power station sustained severe damage, it said.