The couple's organization, the Clooney Foundation for Justice, will open seven public schools in Amal's native Lebanon, reported People magazine.
"Thousands of young Syrian refugees are at risk - the risk of never being a productive part of society. Formal education can help change that. That's our goal with this initiative," the couple said in a joint statement.
"We don't want to lose an entire generation because they had the bad luck of being born in the wrong place at the wrong time."
The collaboration will help the schools provide education services to about 3,000 refugee students who are currently out of school.