Fans or paparazzi will face a 400 pounds fine for loitering round, stopping at or even swimming up to the home on Lake Como until September 30, reported New York Daily News online.
Clooney, 53, plans to marry human rights lawyer Amal Alamuddin , 36, that month but had said he did not want to annoy his neighbours.
The laws announced by Laglio Council are in operation 24 hours a day until September 30. Notices have been stuck on lampposts in the area with a warning in red type.
The new rules were designed to stop them doing the same and to prevent paparazzi from getting too close to his home, he said.
Also Read
"It is now completely forbidden to stop outside the entrance to Clooney's villa. It is a question of traffic and security. It is very dangerous and it's also an issue of privacy," Pozzi said.
Clooney is currently making the most of his Italian mansion and has been taking his fiancee on a number of romantic dates in the area.
Clooney and Amal, who is of British-Lebanese origin, have been engaged since April following a whirlwind romance when they met at a charity event in September.