The 56-year-old actor hinted that he is getting used to the nappy changing as he has to do it regularly, reported FemaleFirst.
"Listen, I'm scared to death, it's terrifying. You're afraid of breaking them. They're so little."
"It's like cleaning up your dog's poop," Clooney told host Jimmy Kimmel on his talk show.
The "Suburbicon" director also said his and lawyer wife Amal Clooney's four-month-old fraternal twins, Ella and Alexander, have recently been introduced to solid food.