Clooney, 52, will be given the award on November 9. The awards honour individuals and companies that have dedicated their careers to advancing the entertainment arts, the Hollywood Reporter said.
"George Clooney is without question one of our industry's true icons. His work has captivated audiences from all corners of the globe, and BAFTA Los Angeles is proud to be celebrating his immeasurable contributions to our craft," said BAFTA Los Angeles chairman Gary Dartnall.