Social Bite co-founder Josh Littlejohn said he approached A-list actor Clooney about visiting the chain and he agreed, reported BBC online.
Social Bite is a social venture which helps the homeless community by allowing customers to pay for food and drink for the vulnerable.
Clooney, 53, will meet employees at the Edinburgh shop on November 12. He will deliver the keynote address at the Scottish Business Awards, also founded by Mr Littlejohn.
The 28-year-old entrepreneur said, "It's a fantastic honour to be bringing one of the world's most famous men to Scotland and it is amazing that he is supporting Social Bite.
"For many of our team who until recently lived on the streets, this is a really amazing thing to look forward to.