Harrison purchased the guitar in 1963 at Fenton's Music store in Mount Vernon, Illinois, while visiting his sister.
The Julien's Auctions sale of rock 'n' roll memorabilia was held on Saturday at the Hard Rock Cafe in New York.
Harrison had the guitar refinished from a Fireglo red to black to match John Lennon's Rickenbacker.
Other items in the sale included Lady Gaga's 1990 Red Rolls-Royce Corniche III automobile. It sold for USD 125,000.