Till Hedrich, who had run Anheuser-Busch InBev's operations in the beer-loving country since January, is leaving the company "with immediate effect", spokesman Oliver Bartelt said in an email.
He said Hedrich, 44, admitted to causing a car crash on a highway south of Munich on April 30 while he was "significantly under the influence of alcohol".
"You can imagine that we, as a company that produces alcohol, have strict internal rules and recommendations for consumers for the enjoyment of alcoholic beverages," Bartelt said.
"That is why the company was so shocked about the account (of the accident) by Hedrich, who serves as a role model in his job," Bartelt said.
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He did not provide further details of the crash.
The director of the giant's European operations, Stuart MacFarlane, will replace Hedrich until a successor is named.
The company, formed in 2008 by the merger of Belgian-Brazilian group InBev and US brewing giant Anheuser-Busch, owns brands including Budweiser, Beck's and Corona. It posted USD 47.1 billion (42.4 billion euros) in sales worldwide last year.