Liverpool midfielder Can and Arsenal defender Mustafi have just over 30 international appearances between them, yet are senior figures in a young Germany squad.
Despite resting nearly all of their World Cup winners and bringing an inexperienced side to Russia, Germany's young guns won Group B and face Mexico at Sochi's Fischt stadium for a place in Sunday's Confed Cup final.
Juan Carlos Osorio's Mexicans had to come from behind in all three of their Group A games, drawing 2-2 with Portugal, then beating both New Zealand and Russia by the same 2-1 margin.
"Mexico remind me a bit of Chile, it's a team which is very aggressive and can play very varied football," said the 25-year-old Arsenal centre-back.
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"They are very organised in defence, experienced players and we'll need to be patient.
"We have to find a way to disrupt them and, a bit like us, they have no superstars."
Mustafi was left on the bench for Sunday's 3-1 win over Cameroon, but is set to feature in a three-man defence against Mexico.
"We'll be well prepared for this game, everyone is looking forward to it," said the 23-year-old.
"They are an uncomfortable opponent, similar to Chile.
"They have very flexible players in a technically strong team, it won't be easy.
"But we have no reason to hide, because we have a strong team.
"No one had expected much from us, but the quality is up there.
"Even if we have never played together before, a lot of things are already working well."
"The Confed Cup is a chance for me to prove what I can do," said Can.
"I am going harder into the challenge -- it's developing me as a player and a person.
"I don't have that many international matches behind me, but I am one of the most experienced here and I will pull the team along.